The influence of hepatitis C virus infection on H1 antihistamine treatment in urticaria patients
نویسندگان
چکیده
Background Considerable evidence indicates that, in addition to antiallergic effect, several H1-antihistamines also possess antiinflammatory properties. The anti-inflammatory activity of H1 antihistamine treatment in urticaria patients is based on the capacity of H1-antihistamines to inhibit the release of chemical mediators from mast cells and basophiles, to regulate the chemotaxis of neutrophils and eosinophils, to increase eosinophils apoptosis and to reduce the expression of the adhesion molecules. Viral hepatic infections may affect the efficacy of H1 antihistamines probably interfering with their hepatic metabolism through cytochrome P450 system. We proposed to analyze the effect of hepatitis C virus (HCV) infection on the therapeutic efficacy of H1 antihistamines in urticaria patients.
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